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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOPBP1
All Species:
20
Human Site:
Y1349
Identified Species:
62.86
UniProt:
Q92547
Number Species:
7
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q92547
NP_008958
1522
170679
Y1349
H
F
V
Q
E
E
D
Y
E
W
G
S
S
S
I
Chimpanzee
Pan troglodytes
XP_516761
1587
177009
Y1414
H
F
V
Q
E
E
D
Y
E
W
G
S
S
S
I
Rhesus Macaque
Macaca mulatta
XP_001112636
1622
181547
Y1449
H
F
V
Q
E
E
D
Y
E
W
G
S
S
S
I
Dog
Lupus familis
XP_534266
1697
189421
Y1524
H
F
V
L
E
E
D
Y
E
W
G
S
S
S
I
Cat
Felis silvestris
Mouse
Mus musculus
Q6ZQF0
1515
168842
Y1345
R
F
V
Q
E
E
D
Y
E
W
G
S
S
S
I
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_524909
1425
158421
G1267
M
L
A
C
I
A
A
G
K
W
I
L
N
I
Q
Honey Bee
Apis mellifera
XP_394416
1192
134009
S1034
H
C
M
Y
L
R
D
S
E
Q
E
G
K
F
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_788169
651
72132
T493
D
L
S
K
L
N
E
T
G
K
K
M
A
V
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.4
91.8
81.1
N.A.
76.8
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
25.2
21.1
N.A.
21.4
Protein Similarity:
100
95.6
93.1
85
N.A.
85.7
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
44.1
38.5
N.A.
30
P-Site Identity:
100
100
100
93.3
N.A.
93.3
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
6.6
20
N.A.
0
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
20
33.3
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
13
0
0
13
13
0
0
0
0
0
13
0
13
% A
% Cys:
0
13
0
13
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
13
0
0
0
0
0
75
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
63
63
13
0
75
0
13
0
0
0
0
% E
% Phe:
0
63
0
0
0
0
0
0
0
0
0
0
0
13
0
% F
% Gly:
0
0
0
0
0
0
0
13
13
0
63
13
0
0
0
% G
% His:
63
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
13
0
0
0
0
0
13
0
0
13
63
% I
% Lys:
0
0
0
13
0
0
0
0
13
13
13
0
13
0
0
% K
% Leu:
0
25
0
13
25
0
0
0
0
0
0
13
0
0
13
% L
% Met:
13
0
13
0
0
0
0
0
0
0
0
13
0
0
0
% M
% Asn:
0
0
0
0
0
13
0
0
0
0
0
0
13
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
50
0
0
0
0
0
13
0
0
0
0
13
% Q
% Arg:
13
0
0
0
0
13
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
13
0
0
0
0
13
0
0
0
63
63
63
0
% S
% Thr:
0
0
0
0
0
0
0
13
0
0
0
0
0
0
0
% T
% Val:
0
0
63
0
0
0
0
0
0
0
0
0
0
13
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
75
0
0
0
0
0
% W
% Tyr:
0
0
0
13
0
0
0
63
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _